Highlights
Epitope tags: Explained
IPI epitope tag antibodies, delivered via an open science model, aim to increase access, cut costs and enhance reproducibility. Maybe this story is yours. You’ve got a protein you want…
IPI’s community-centered approach to antibody discovery: A Q&A with Rob Meijers
This spring, the Institute for Protein Innovation (IPI) dispatched a collection of antibodies targeting members of the elusive integrin receptor family. Those antibodies, shared with researchers around the world through…
Cell signaling, Sonic Hedgehog and Hemingway’s cats: A Q&A with Adrian Salic
In 1980, the famous geneticists Christiane Nüsslein-Volhard and Eric Wieschaus were mapping embryonic mutations in the model organism Drosophila melanogaster, known colloquially as the fruit fly. They found that when…
IPI antibody helps illuminate the MYCN-mediated tumor microenvironment
If you were diagnosed with aggressive neuroblastoma, you’d most likely be an infant carrying a genetic change that sprang up in your nerve cells before you were born. That change…
“A wise man always keeps learning”: Biotech entrepreneur Rusty Williams joins IPI Board
In 1984, Lewis “Rusty” Williams boarded a flight from Boston to San Francisco and took the last open seat near the back of the plane. Williams, then a doctor and…
Engineering for efficiency: André Teixeira takes charge of antibody discovery and library design at IPI
It’s a few minutes after noon, and scientists at the Institute for Protein Innovation (IPI) are eating in the conference room. The conversation turns to IPI’s antibody display library —…
Entry points into neuroscience: A Q&A with Thomas Biederer
At the heart of all nervous system functions are the synapses, where signals fly between neurons in swarms of molecular activity. Thomas Biederer is intent on prying open the compartments’…
At Cell Bio 2023, a multidisciplinary panel suggests solutions for antibody validation
Antibodies are among biologists’ most essential tools, but many just don’t work. Worse, many researchers who rely on these protein-binding reagents don’t know the pitfalls. According to YCharOS, a Canadian…
For IPI Board member Auro Nair, biotech is an outlet for good
Growing up in Malaysia, Auro Nair learned two basic tenets from his parents: Be a good person and do well in school. These maxims may have seemed simplistic to a…
Dissecting the nervous system’s self-assembly toolkit: A Q&A with Alex Jaworski
Early in development, an embryo begins an epic undertaking: the building of its nervous system. As part of the process, neurons send out axons on extraordinary journeys to distant targets.…
Bespoke high-throughput approach expedites screening of cell-surface ectodomains
Cell-surface receptors are notoriously tricky to produce and purify; they misfold, aggregate, degrade, and often express poorly. Researchers can get past these roadblocks by focusing on the ectodomain, the region…
Panel highlights antibody characterization and validation strategies
Biology’s shortage of high-quality, well-performing and easily accessible antibodies is no breaking news; it’s a challenge that has been painfully experienced and well-documented for years. Many researchers have called for…
IPI antibody helps illuminate the MYCN-mediated tumor microenvironment
If you were diagnosed with aggressive neuroblastoma, you’d most likely be an infant carrying a genetic change that sprang up in your nerve cells before you were born. That change…
At Cell Bio 2023, a multidisciplinary panel suggests solutions for antibody validation
Antibodies are among biologists’ most essential tools, but many just don’t work. Worse, many researchers who rely on these protein-binding reagents don’t know the pitfalls. According to YCharOS, a Canadian…
At IPI Surfacing, panel calls for long-overdue collaboration to improve antibody reliability and accessibility
In a perfect world, antibody reagents would be reliable. Their protein sequences would be accessible. Application testing would have been conducted before sales. And protein tools would be affordable, proffered…
Uncovering the secrets of mechanotransduction, one integrin receptor at a time
For the body to function, cells must decide. Embryonic cells elect to reproduce and shape into budding limbs. Immune cells choose to leave the bloodstream en route to an infection…
New federation aims to transform biology with protein tools spanning proteome by 2035
An ambitious protein moonshot is gaining momentum to develop and widely share tools that will land us understanding of the complete human proteome. In 2003, biology was all about the…
From Rob Meijers, interim executive director: In 2021, IPI explored ‘new frontiers’ in antigen and antibody discovery
As the world struggled to live in and through a seeming “forever pandemic,” 2021 was a year that demanded global resilience. The potency of delta followed by fast spread of…
A mystery launched a decade-long quest, leading to a novel cause of bone marrow failure
Twelve years ago, after a routine check-up of a newborn, a medical resident inadvertently ordered a nonroutine blood test. The results came as a surprise: The infant had virtually no…
Ubiquitous yet less severe, did omicron sacrifice virulence to evade immunity?
According to conventional wisdom, a SARS-CoV-2 variant becomes more infectious when it mutates to better bind and invade host cells. But a new study on omicron, which carries quadruple the…
Youssef Atef AbdelAlim carries protein science lessons to medical school
For IPI research associate Youssef Atef AbdelAlim, science is synonymous with patient care. He’s run antibody discovery sorts, engineered protein libraries and performed fluorescence microscopy. He’s rounded the clinics, organized…
Innovation comes naturally to IPI’s director of automation Curtis Walton
When Curtis Walton was young, he’d disassemble household items, diligently learning about their inner mechanisms as he reassembled them. Growing up in Sarnia, Ontario, he pulled off this exercise on…
IPI’s community-centered approach to antibody discovery: A Q&A with Rob Meijers
This spring, the Institute for Protein Innovation (IPI) dispatched a collection of antibodies targeting members of the elusive integrin receptor family. Those antibodies, shared with researchers around the world through…
Cell signaling, Sonic Hedgehog and Hemingway’s cats: A Q&A with Adrian Salic
In 1980, the famous geneticists Christiane Nüsslein-Volhard and Eric Wieschaus were mapping embryonic mutations in the model organism Drosophila melanogaster, known colloquially as the fruit fly. They found that when…
“A wise man always keeps learning”: Biotech entrepreneur Rusty Williams joins IPI Board
In 1984, Lewis “Rusty” Williams boarded a flight from Boston to San Francisco and took the last open seat near the back of the plane. Williams, then a doctor and…
Engineering for efficiency: André Teixeira takes charge of antibody discovery and library design at IPI
It’s a few minutes after noon, and scientists at the Institute for Protein Innovation (IPI) are eating in the conference room. The conversation turns to IPI’s antibody display library —…
Entry points into neuroscience: A Q&A with Thomas Biederer
At the heart of all nervous system functions are the synapses, where signals fly between neurons in swarms of molecular activity. Thomas Biederer is intent on prying open the compartments’…
For IPI Board member Auro Nair, biotech is an outlet for good
Growing up in Malaysia, Auro Nair learned two basic tenets from his parents: Be a good person and do well in school. These maxims may have seemed simplistic to a…
Dissecting the nervous system’s self-assembly toolkit: A Q&A with Alex Jaworski
Early in development, an embryo begins an epic undertaking: the building of its nervous system. As part of the process, neurons send out axons on extraordinary journeys to distant targets.…
Jazz and a journey to biotech: Issi Rozen brings creative spirit to IPI Board
Becoming a jazz guitarist starts with a soul-catching chord. That initial spark of inspiration is followed by hours of practice to learn scales and complex harmonies, decades of determination to…
Epitope tags: Explained
IPI epitope tag antibodies, delivered via an open science model, aim to increase access, cut costs and enhance reproducibility. Maybe this story is yours. You’ve got a protein you want…
Engineering Protein A to Z for VH3 antibody purification
Antibody purification is often taken for granted. It’s an essential step in isolating desirable antibodies for research and drug development and a standard part of antibody production at the Institute…
Inside the IPI pipeline
Of the tools underpinning biomedical research, antibodies are among the most impactful. Their ability to recognize and attach to biomolecules has powered fundamental discoveries, diagnostic methods and treatments for diseases,…
Integrins: Explained
More than 600 million years ago, out of the depths of the metazoa, a protein family emerged — one that would persist through evolution and come to shape life today.…
The Institute for Protein Innovation and Addgene partner to accelerate biomedical discovery with the development and distribution of protein-binding reagents
Partnership joins two nonprofits with aligned missions to provide researchers with access to well-validated antibodies and other reagents—and expertise about where and how to use them Boston, June 8, 2023…
Harvard professor and entrepreneur Tim Springer donates $210 million to the Institute for Protein Innovation
The gift further positions the emerging nonprofit to transform biomedical research with novel protein tools and expertise BOSTON, March 29, 2023 — The Institute for Protein Innovation (IPI), a nonprofit…
Institute for Protein Innovation welcomes top researchers at first symposium
BOSTON, March 29, 2023 — The Institute for Protein Innovation (IPI) will host IPI Surfacing, a symposium on cell surface receptor biology, on Thursday, June 15, 2023. The free, day-long…
Institute for Protein Innovation welcomes esteemed industry leader Kenneth Fasman, Ph.D. as president and chief executive officer
Boston, November 15, 2022 — The Institute for Protein Innovation (IPI), a nonprofit research organization advancing protein science to accelerate biomedical research and improve human health, today announced the appointment…
AI Proteins secures $18.2 million seed round to pioneer high-throughput platform for advanced miniprotein therapeutics
Company to focus on the rapid development of miniproteins tailor-made for therapeutics, driving down costs and shortening the time required to develop safer, more effective medicines. BOSTON—(BUSINESS WIRE)—AI Proteins, the…
IPI co-founder Timothy Springer wins Lasker Award, highlighting key chapter in biology
Scientist, entrepreneur and philanthropist Timothy Springer is one of three scientists to win the 2022 Albert Lasker Award for Basic Medical Research, widely regarded as America’s top biomedical research prize.…
IPI joins an exciting effort to solve the reproducibility crisis
IPI is thrilled to join YCharOS as a member of its new Industry Advisory Committee. The Canadian company, named from a truncation of Antibody Characterization through Open Science, is launching…
Christopher Bahl selected as a TED Fellow
Institute for Protein Innovation Head of Protein Design to present at TED2019, joining the newest class of 20 global visionaries. BOSTON, Jan. 23, 2019 /PRNewswire/ — Molecular Engineer Chris Bahl…
IPI appoints Wei Yang as director of target discovery and Sharon Klein as director of philanthropy
Boston, June 26, 2018 /PR Newswire/ – Institute for Protein Innovation (IPI), a non-profit research organization focused on empowering research in protein science and developing open-source monoclonal antibodies, announced today…
IPI relocates to Boston’s Longwood Medical and Academic Area
BOSTON, May 21, 2018 /PRNewswire/ — Just one year after launch, IPI has relocated to the Harvard Institutes of Medicine at 4 Blackfan Circle, Boston. The 12,000-square-foot lab space represents a dramatic expansion and…