Integrin antibody collection

Our integrin collection includes antibodies that bind discrete subunits or particular subunit pairs. The antibodies block ligand binding, interrupt integrin function and/or identify integrin presence. Scientists can use IPI antibodies to study signaling, test mechanisms or ascertain distinct receptor functions — all key to drug development.

The anti-integrin toolset comprises 11 synthetic recombinant antibodies developed at IPI using yeast display technology and 15 hybridoma-derived antibodies developed in the Springer lab and produced at IPI.

All IPI antibodies go through extensive characterization, including:

• Molar mass verification via mass spectrometry
• Purity and structural integrity analysis via size exclusion chromatography
• Affinity and kinetics measurements via surface plasmon resonance
• Non-specific binding assessment via polyspecificity reagent assay testing
• Activity analysis via flow cytometry

IPI’s anti-integrin antibodies are unconjugated and recommended for use in flow cytometry. IPI is also expanding antibody characterization to other applications, including western blot, immunohistochemistry, ELISA, immunoprecipitation, and immunofluorescence.

At IPI, we believe that finding the right reagent shouldn’t be so difficult. Thus, IPI offers its antibody purchasers access to data including antibody sequences, affinity results and kinetic behavior.