Institute for Protein Innovation (IPI), a nonprofit research organization in the Harvard Medical School/Longwood Medical Area and premier center for protein science, seeks a Production Scientist to be responsible for running and improving upon existing protein production pipelines. The position will also involve managing specific protein and antibody production projects with the goal of providing open source antibodies to the community for testing. The ideal candidate will be capable of performing high-throughput screening and production of a diverse assortment of secreted and non-secreted proteins cultured in HEK cells using several automation platforms. IPI operates a state-of-the-art platform for high-throughput discovery of antibodies targeting the entire human and mouse extracellular proteome that will serve as leads for new therapeutics and open-source research tools. The candidate will play an integral leadership role in shaping the direction of programs at IPI.
Express proteins using transient transfection in Expi293 cells using high-throughput, automated liquid handing methods
Perform HT screens, hit identification, and data analysis
Manage and manipulate hundreds of proteins using automated processes at 384well scale
Present reports and results to group meetings
Data management using a LIMS
Maintain automation systems
PhD in protein chemistry, cell biology, molecular biology, or closely related fields with automation and liquid handling experience
Experience with protein characterization techniques such as SDS-PAGE, Western blot, SEC, HPLC
Excellent organizational skills and ability to simultaneously manage multiple projects
Strong communication, interpersonal skills, and leadership is required
Adapt to rapid changes in projects priorities and timelines
Experience with liquid handling platforms (Biomek, Lynx, Tecan, Hamilton)
Experience with analytical and developability assays for antibody characterization
Knowledge of scripting language (python, etc)
Interested candidates should send a CV and a brief statement of future research interests as a single PDF to firstname.lastname@example.org. Please include “Production Scientist” in the subject line.
IPI offers competitive compensation and benefits, including health and dental insurance, generous vacation and holiday time off, and retirement saving plans. IPI is an Equal Opportunity /Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to their race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status or disability.