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Reports to the Director of the Antibody Platform

The Institute for Protein Innovation (IPI) is a nonprofit research organization advancing protein science to accelerate research and improve human health. Located on the Harvard Medical School campus in the Boston Longwood Medical Area, IPI uniquely combines the freedom of academia with the high-throughput scaling of industry to take on transformative projects. IPI has built a robust platform and a repository of synthetic antibodies and other protein tools to share with the biomedical community through licensing and collaboration. The Institute’s deep protein expertise, collaborative spirit and fit-for-purpose antibodies are powering new biomedical and therapeutic discoveries for academic and industrial researchers worldwide.

Job Overview

The Scientist Biophysical Characterization will play an essential role in the characterization and quality control of IPI’s human synthetic antibodies, produced for a wide range of cell surface receptors and ligands. IPI’s flagship project, the “Antibody Initiative,”aims to create well-characterized, fit-for-purpose antibodies, with high therapeutic and diagnostic potential, for all human cell surface receptors and their ligands.. The successful candidate will be a key member of the team that characterizes our antigens and antibodies produced in mammalian cells. Specifically, the Scientist will bring expertise in biophysical experimentation and analysis, with a rigorous background in protein kinetics and statistical analysis. The Scientist will have proven experience in mass spectrometry, surface plasmon resonance, protein purification and light scattering techniques The Scientist will work in close collaboration with the other members of the Antibody Platform and will contribute to a wide array of biological discovery projects. Strong communication skills are needed to facilitate the engagement of IPI with outside collaborators to translate their biological questions into novel protein reagents and to share them with the larger research community.

Responsibilities and Duties

●  Operate and maintain biophysical equipment, including a maXis QTOF mass spectrometer, a Carterra high-throughput SPR machine and an HTX Octet BLI machine

●  Supervise research associates who provide daily quality control on the antigens and antibodies produced within the platform

●  Establish standard operating protocols for dynamic and static light scattering, antigen/antibody kinetics and mass spectrometry

●  Produce publication-quality data analysis on antigen/antibody binding properties and chemical composition

●  Strategize how different antigen and antibody properties may enable versatile use of our antibodies for the life sciences

●  Participate in meetings and conferences to engage and recruit outside research groups to participate in the Antibody Initiative

Qualifications

●  PhD degree and at least five years experience in biophysics or structural biology (Candidates with more experience will be considered for a senior scientist position.)

●  Experienced in utilizing relevant biophysics software for data analysis

●  Enthusiastic team worker with strong engagement in tool development for the life sciences

IPI is an independent 501(3)(c) nonprofit research organization and an equal opportunity employer. The Institute celebrates diversity and is committed to creating an inclusive environment for all employees. If interested, please email your resume to careers@proteininnovation.org.

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