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Reports to the Director of the Antibody Platform

The Institute for Protein Innovation (IPI) is a nonprofit research organization advancing protein science to accelerate research and improve human health. Located on the Harvard Medical School campus in the Boston Longwood Medical Area, IPI uniquely combines the freedom of academia with the high-throughput scaling of industry to take on transformative projects.  IPI has built a robust platform and a repository of synthetic antibodies and other protein tools to share with the biomedical community through licensing and collaboration. The Institute’s deep protein expertise, collaborative spirit and fit-for-purpose antibodies are powering new biomedical and therapeutic discoveries for academic and industrial researchers worldwide.

Job Overview

The Principal Scientist Antibody Discovery will play an essential role in the discovery by yeast display of IPI’s human synthetic antibodies, produced for a wide range of cell surface receptors and ligands. IPI’s flagship project, the “Antibody Initiative,” aims to create well-characterized, fit-for-purpose antibodies, with high therapeutic and diagnostic potential, for all human cell surface receptors and their ligands. The successful candidate will be a key member of the Antibody Discovery team that develops yeast cell displaying human FAB fragments that bind to antigens produced by the Protein Production team. Specifically, the Principal Scientist will bring expertise in yeast molecular biology and cell sorting techniques. The Principal Scientist will have proven experience in yeast display, yeast genetics, cell sorting and synthetic biology techniques. The Principal Scientist will work in close collaboration with the other members of the Antibody Platform and will contribute to a wide array of biological discovery projects. Strong communication skills are also needed to facilitate the engagement of IPI with outside collaborators to translate their biological questions into novel protein reagents and to share them with the larger research community.

Responsibilities and Duties

  • Design and perform yeast display experiments in high throughput
  • Establish standard operating protocols for MACS and FACS techniques with the aim to obtain strong human FAB binders for a diverse range of antigens
  • Produce publication-quality data analysis on sorting experiments
  • Develop new FAB libraries for cell display to further enrich our antibody diversity repertoire
  • Develop custom sorting protocols to discover binders for protein complexes as well as their individual components
  • Participate in meetings and conferences to engage and recruit outside research groups to participate in the Antibody Initiative
  • Supervise research associates and interact with colleagues within the Antibody Platform to enable highly efficient antibody discovery campaigns


  • PhD degree in biochemistry, molecular biology or a related field
  • Significant experience working with display technologies to identify high-affinity binders
  • Experience with sophisticated molecular biology engineering methods
  • Familiarity with the kinetics of protein/protein interactions
  • Enthusiastic team worker with strong engagement in tool development for the life sciences

IPI is an independent 501(3)(c) nonprofit research organization and an equal opportunity employer. The Institute celebrates diversity and is committed to creating an inclusive environment for all employees. If interested, please email your resume to



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